Aspirin has been used in crushed form as an acne treatment ingredient for homemade masks.  It has been known to reduce inflammation when taken internally of course, and it has been used in various professionally made treatment creams, serums, etc to again reduce inflammation that may cause acne to look worse, cause wrinkles, or otherwise cause skin damage in general as a result of other things for the most part such as sun damage and bacteria for example.  But it has been used in various forms. 

You can of course get the aspirin you find in pills, which is rather easy to crush up for the most part.  But you can also get one called white willow bark.  No matter which one you choose, you basically mix it with water, and it also has the tendency to wash away dead skin cells from the face while otherwise reducing excess oils and other problems.  Aspirin is one of the best ingredients for your generalized needs.  It is an easy mask to use, convenient, and yet extremely effective while also being of course extremely cheap.  So at the very least, it’s one to consider if you are looking for a serious acne treatment.